Coronavirus Thread VI: Are We Nearly There Yet? (READ OP)

[National Capitalist United States]

these are all back from when he first endorsed it on Fox News post-presidency

Stay in school kids and don't do drugs... Or else you'll end up like these QAnon folks.

If the Democrats were more harsh on drugs, these people would definetly be on an anti-drug PSA

[Loeje]

When you hit them with facts, they either don't wanna talk about it anymore or says "I DONT CARE. WE'RE GOING TO MAKE AMERICA GREAT AGAIN."

Actually, that sounds relatively sane. My experience is more that they keep claiming something will happen, that I will see and that I should do more research.

Where of course the dates always move further back, all the big reveals turn out to be duds and when I present my research and ask them to point out where I "went wrong" according to them they ofc never answer; because they themselves never did any research and just parrot what they were told..

But they believe they did research and that they are right. It is a fullblown religion.

It's much less rational than any religion. QAnon is a cult.

[The Black Forrest]

When you hit them with facts, they either don't wanna talk about it anymore or says "I DONT CARE. WE'RE GOING TO MAKE AMERICA GREAT AGAIN."

Actually, that sounds relatively sane. My experience is more that they keep claiming something will happen, that I will see and that I should do more research.

Where of course the dates always move further back, all the big reveals turn out to be duds and when I present my research and ask them to point out where I "went wrong" according to them they ofc never answer; because they themselves never did any research and just parrot what they were told..

But they believe they did research and that they are right. It is a fullblown religion.

Indeed. Though one of mine did come around and admit he was caught up in the message and later found the ex-president was mainly talk and really didn't do that much.

[Kowani]

who could have seen that coming

[Nakena]

Asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19

Inhaled budesonide, a common corticosteroid, is the first widely available, inexpensive drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings, reports the UK’s PRINCIPLE trial in 1,779 participants.

Early treatment with inhaled budesonide shortens recovery time by a median of three days in patients with COVID-19 who are at higher risk of more severe illness and are treated in the community, finds Oxford University’s Platform Randomised Trial of Interventions against COVID-19 in Older People (PRINCIPLE) trial.

PRINCIPLE is the world’s largest Phase 3 platform randomised controlled trial to find clear evidence of an effective COVID-19 treatment for use in the community that can significantly shorten recovery time. As one of the UK Government’s national priority platform trials, findings from PRINCIPLE have potential to change how COVID-19 is treated in its early stages in non-hospital, community settings in the UK and internationally.

Inhaled budesonide is a safe, relatively inexpensive and readily available corticosteroid commonly used around the world in inhalers to treat asthma and chronic obstructive pulmonary disease. It was added to the PRINCIPLE trial on 28th November 2020.

Recruitment for the inhaled budesonide arm of the trial stopped on 31st March 2021 since, in the view of the Trial Steering Committee, enough patients had been enrolled to establish whether or not the drug had any meaningful benefit on time to recovery. Obtaining further data on hospital admissions or death was unlikely due to the reducing number of cases in the UK.

For the interim report, a total of 961 patients were randomly assigned to receive inhaled budesonide at home and were compared with 1819 patients randomly assigned to the usual standard of NHS care alone. Of these, 751 people in the budesonide group and 1028 in the usual care group were SARS-CoV-2 positive and included in the primary interim analysis.

Based on the interim analysis using the latest data from 25th March 2021, the results showed the estimated median time to self-reported recovery for inhaled budesonide was 3.011 days shorter compared to usual care (95% Bayesian credible interval 1.134 to 5.410 days), with a high probability (0.999) of being superior to the usual standard of care. 32% of those taking inhaled budesonide, compared to 22% in the usual care group, recovered within the first 14 days since being randomised into the trial and subsequently have remained well until 28 days (relative risk 1.46, 95% CI 1.23 - 1.74). Participants in the budesonide group also reported greater wellbeing after two weeks (mean difference in WHO-5 Wellbeing score + 3.37 ,95% CI 0.97 – 5.76, p = 0.006).

Among patients who had completed all 28 days of study follow up by 25th March 2021, 8.5% (59/692) in the budesonide group were hospitalised with COVID-19 compared with 10.3% (100/968) in the usual care group (estimated percentage benefit, 2.1% [95% BCI -0.7% – 4.8%], probability of superiority 0.928). Since fewer than expected people were admitted to hospital in the trial, and with COVID-19 cases and hospitalisations continuing to drop in the UK, it is not clear from this interim analysis whether budesonide reduces hospitalisations.

Patients with COVID-19 symptoms that started within 14 days and who are at higher risk of a poor outcome from the illness could join the trial and those with a positive SARS-CoV-2 result were included in the main analysis. Patients treated with inhaled budesonide were asked to inhale 800 micrograms twice a day for 14 days and were followed-up for 28 days. All patients were aged over 50 with an underlying health condition that put them at more risk of serious COVID-19 illness, or aged over 65.

Joint Chief Investigator, Professor Chris Butler, a South Wales GP and Professor of Primary Care from the University of Oxford’s Nuffield Department of Primary Care Health Sciences, said, ‘PRINCIPLE, the world’s largest platform trial of community-based treatments for COVID-19, has found evidence that a relatively cheap, widely available drug with very few side effects helps people at higher risk of worse outcomes from COVID-19 recover quicker, stay better once they feel recovered, and improves their wellbeing. We therefore anticipate that medical practitioners around the world caring for people with COVID-19 in the community may wish to consider this evidence when making treatment decisions, as it should help people with COVID-19 recover quicker.

‘This exciting finding about the beneficial effects of inhaled budesonide would not have been possible without the contribution of those patients who volunteered to participate: your gift of taking part will help doctors and nurses provide better evidence-based care for people with COVID-19 worldwide. It also stands as a monument to the far-sighted funders of PRINCIPLE, the UK-wide clinical research networks who have been absolutely key to the successful implementation of the trial, all the general practices and clinicians who support PRINCIPLE, NHS Digital, HDRUK, the Therapeutics Task Force and the hard work and dedication of our study team and oversight committees in the Primary Care Clinical Trials Unit.’

Joint Chief Investigator, Professor Richard Hobbs, Head of Oxford University’s Nuffield Department of Primary Care Health Sciences, said, ‘For the first time we have high-quality evidence of an effective treatment that can be rolled out across the community for people who are at most risk of developing more severe illness from COVID-19. Unlike other proven treatments, budesonide is effective as a treatment at home and during the early stages of the illness. This is a significant milestone for this pandemic and a major achievement for community-based research.’

Professor Mona Bafadhel, from Oxford University’s Nuffield Department of Medicine, and a Consultant Respiratory Physician, led the earlier STOIC Phase 2 efficacy study of inhaled budesonide for early COVID-19 and led the development of the budesonide study arm for PRINCIPLE. She said, ‘The news that the findings of the earlier-phase STOIC trial, which reported at the beginning of the year, have been replicated at scale here in the PRINCIPLE trial is outstanding. We are now sure that we have a treatment that will benefit patients with early COVID-19 worldwide Inhaled budesonide is readily available worldwide and commonly used to treat asthma and chronic obstructive pulmonary disease.’

Professor Fiona Watt, Executive Chair of the Medical Research Council, which co-funded the study, said, ‘Researchers involved in the PRINCIPLE trial have overcome considerable logistical hurdles to set up a world-leading rigorous drug trial in people’s homes. We are now rewarded with the first inexpensive and widely available drug that can shorten recovery times for COVID-19 patients in the community. People around the world will be helped to recover faster thanks to these exciting new results.’

As soon as all remaining patients in the trial have completed their follow-up and a full analysis has been completed, detailed results on time to recovery and hospitalisations will be published. For this preliminary report, 92.8% of people randomised to the budesonide arm had the opportunity to complete 28 days of follow-up. To read the full pre-print, visit the MedRxiv server.

PRINCIPLE is funded by a grant to the University of Oxford from UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research as part of the UK Government’s rapid research response fund.

https://www.ox.ac.uk/news/2021-04-12-as ... s-covid-19

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[North Washington Republic]

(Image)
who could have seen that coming

Tomorrow will be the two weeks since I received the J&J. After three days, I had no serious side effects. The first couple of days there was minor muscle aches, Nothing serious. I must say that I’m am worried, even though I’m a cisgender male, and all of the people that had serious side effects were women.

[Nakena]

(Image)
who could have seen that coming

Tomorrow will be the two weeks since I received the J&J. After three days, I had no serious side effects. The first couple of days there was minor muscle aches, Nothing serious. I must say that I’m am worried, even though I’m a cisgender male, and all of the people that had serious side effects were women.

The blod clot problem is reported to happen in the first days post vaccination. With two weeks passed you are likely out of the dangerzone.

Recently there have been reports of a very rare condition involving blood clots and unusual bleeding after vaccination. This is being carefully reviewed but the risk factors for this condition are not yet clear.

Although this condition remains extremely rare there appears to be a higher risk in people shortly after the first dose of the AstraZeneca (AZ) vaccine. Around 4 people develop this condition for every million doses of AZ vaccine doses given.

This is seen slightly more often in younger people and tends to occur between 4 days and 2 weeks following vaccination.

This condition can also occur naturally, and clotting problems are a common complication of COVID-19 infection. An increased risk has not yet been seen after other COVID-19 vaccines but is being carefully monitored.

https://www.gov.uk/government/publicati ... d-clotting

[North Washington Republic]

Tomorrow will be the two weeks since I received the J&J. After three days, I had no serious side effects. The first couple of days there was minor muscle aches, Nothing serious. I must say that I’m am worried, even though I’m a cisgender male, and all of the people that had serious side effects were women.

The blod clot problem is reported to happen in the first days post vaccination. With two weeks passed you are likely out of the dangerzone.

Recently there have been reports of a very rare condition involving blood clots and unusual bleeding after vaccination. This is being carefully reviewed but the risk factors for this condition are not yet clear.

Although this condition remains extremely rare there appears to be a higher risk in people shortly after the first dose of the AstraZeneca (AZ) vaccine. Around 4 people develop this condition for every million doses of AZ vaccine doses given.

This is seen slightly more often in younger people and tends to occur between 4 days and 2 weeks following vaccination.

This condition can also occur naturally, and clotting problems are a common complication of COVID-19 infection. An increased risk has not yet been seen after other COVID-19 vaccines but is being carefully monitored.

https://www.gov.uk/government/publicati ... d-clotting

The CDC says three weeks for J&J. So, one more week for me.

[Nanatsu no Tsuki]

I feel less intelligent after reading those moronic posts.

You shall hear from my solicitor in the morning, sir. Hmph. /j

I'd seen this warning, and I read the spoiler anyway.

Why, oh why, did I read the spoiler. I lost a minute of my life and feel so... *shudder*.

They must make their minds twist in more contortions than a Stretch Armstrong toy.

They ought to get at least a bronze medal in the next Olympic Games. If only for those huge mental gymnastics they engage in.

Loons.

[Major-Tom]

these are all back from when he first endorsed it on Fox News post-presidency

Smh the mental gymnastics these people will do to justify their bizarre claims

Did all the lead paint in this country just dropkick their brains back to infancy? I don't get it.

[Alcala-Cordel]

Got my first Pfizer shot the other day and it's a huge relief.

[The Black Forrest]

Got my first Pfizer shot the other day and it's a huge relief.

Congrats! I got mine last week. The second will be on the 30th.

[Shazbotdom]

I keep hearing about this "blood clot" issue and how it's so dangerous. It's 1,000,000 in 1 of a chance to get it. There's a 100,000 to 1 chance of women getting blood clots from Birth Control and they haven't suspended the sale and distribution of those. Seems like overkill to me for them to suspend the J&J Vaccine over something that is a much lower chance of getting blood clots than other things.

[Rusozak]

I keep hearing about this "blood clot" issue and how it's so dangerous. It's 1,000,000 in 1 of a chance to get it. There's a 100,000 to 1 chance of women getting blood clots from Birth Control and they haven't suspended the sale and distribution of those. Seems like overkill to me for them to suspend the J&J Vaccine over something that is a much lower chance of getting blood clots than other things.

I'm too tired to do the math but I think you have a higher chance of spontaneously dying by brain aneurysm than getting blood clots from the vaccine.

[The Black Forrest]

I keep hearing about this "blood clot" issue and how it's so dangerous. It's 1,000,000 in 1 of a chance to get it. There's a 100,000 to 1 chance of women getting blood clots from Birth Control and they haven't suspended the sale and distribution of those. Seems like overkill to me for them to suspend the J&J Vaccine over something that is a much lower chance of getting blood clots than other things.

So? You are ok with it happening to you?

[Nanatsu no Tsuki]

Got my first Pfizer shot the other day and it's a huge relief.

Congrats! I got mine last week. The second will be on the 30th.

I get my second Moderna shot on May 4th.

[Kowani]

Pfizer CEO Albert Bourla says it’s likely that people’ll need annual booster shots

[The Black Forrest]

Congrats! I got mine last week. The second will be on the 30th.

I get my second Moderna shot on May 4th.

Cool! More shots means less strain on the ICU.

[The Black Forrest]

Pfizer CEO Albert Bourla says it’s likely that people’ll need annual booster shots

Not surprised. Kind of figured this would be the new flu shot.

[Borderlands of Rojava]

One thing I will not miss about the covid pandemic is the sheer lack of nuance from anyone other than the science community. Half of America thinks it's the common cold and the other half acts like it's captain trips and both are wrong.

[Borderlands of Rojava]

Pfizer CEO Albert Bourla says it’s likely that people’ll need annual booster shots

Not surprised. Kind of figured this would be the new flu shot.

Hopefully the additional ones don't cause the same fatigue and shit as the second dose does.

[Neanderthaland]

Not surprised. Kind of figured this would be the new flu shot.

Hopefully the additional ones don't cause the same fatigue and shit as the second dose does.

I'm guessing they will. A lot of that is just your immune system reacting to the vaccine. A strong reaction to the second shot is a sign that the first one was successful in training your immune system.

And for obvious reasons, you would want to give a booster shot somewhat before most people have lost their immunity.

[Xmara]

One thing I will not miss about the covid pandemic is the sheer lack of nuance from anyone other than the science community. Half of America thinks it's the common cold and the other half acts like it's captain trips and both are wrong.

The thing I won't miss is having to wear a mask everywhere. I'll do it to protect others, but I hate wearing it with a passion.

[Xmara]

Pfizer CEO Albert Bourla says it’s likely that people’ll need annual booster shots

Not surprised. Kind of figured this would be the new flu shot.

I don't care as long as it controls the pandemic enough so normal life can resume and I don't have to live in a state of near-constant anxiety.

[Shazbotdom]

I keep hearing about this "blood clot" issue and how it's so dangerous. It's 1,000,000 in 1 of a chance to get it. There's a 100,000 to 1 chance of women getting blood clots from Birth Control and they haven't suspended the sale and distribution of those. Seems like overkill to me for them to suspend the J&J Vaccine over something that is a much lower chance of getting blood clots than other things.

So? You are ok with it happening to you?

I"m just saying, if we are going to suspend the J&J for it, then we need to suspend the disbursal and sale of all Birth Control due to the same issue. Otherwise, it's serious fearmongering.