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The Sunshine, Daisies, and Lollipops Happy Stuff Thread

For discussion and debate about anything. (Not a roleplay related forum; out-of-character commentary only.)

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Chan Island
Negotiator
 
Posts: 5543
Founded: Nov 26, 2015
Inoffensive Centrist Democracy

Postby Chan Island » Sun Apr 18, 2021 10:55 am

The sun's out, we in Britain can at last legally go outside, and my friends are reconnecting with me. Today has not been so bad. :)
Conserative Morality wrote:"It's not time yet" is a tactic used by reactionaries in every era. "It's not time for democracy, it's not time for capitalism, it's not time for emancipation." Of course it's not time. It's never time, not on its own. You make it time. If you're under fire in the no-man's land of WW1, you start digging a foxhole even if the ideal time would be when you *aren't* being bombarded, because once you wait for it to be 'time', other situations will need your attention, assuming you survive that long. If the fields aren't furrowed, plow them. If the iron is not hot, make it so. If society is not ready, change it.

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Thepeopl
Minister
 
Posts: 2009
Founded: Feb 24, 2019
Democratic Socialists

Postby Thepeopl » Tue Apr 20, 2021 5:10 am


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The New California Republic
Post Czar
 
Posts: 34054
Founded: Jun 06, 2011
Civil Rights Lovefest

Postby The New California Republic » Tue Apr 20, 2021 5:12 am

Thepeopl wrote:https://www.syfy.com/syfywire/new-species-of-cuckoo-wasp-found-in-norway

Its soo pretty!

I took a look at the images and thought it was false colour images at first until I read the article, as the sciences sometimes use those.
Last edited by Sigmund Freud on Sat Sep 23, 1939 2:23 am, edited 999 times in total.

The Irradiated Wasteland of The New California Republic: depicting the expanded NCR, several years after the total victory over Caesar's Legion, and the annexation of New Vegas and its surrounding areas.

White-collared conservatives flashing down the street
Pointing their plastic finger at me
They're hoping soon, my kind will drop and die
But I'm going to wave my freak flag high
Wave on, wave on
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San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Tue Apr 20, 2021 11:04 am

Watched the inauguration of Tishaura Jones as the first black female mayor of St Louis online. Such an inspiring moment and was grateful I could watch it.
Last edited by San Lumen on Tue Apr 20, 2021 11:08 am, edited 1 time in total.


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Kowani
Post Czar
 
Posts: 37922
Founded: Apr 01, 2018
Democratic Socialists

Postby Kowani » Wed Apr 21, 2021 12:58 am

'Undruggable' cancer protein becomes druggable

Inspired by a rare compound found in a shrub native to North America, Mingji Dai, professor of chemistry and a scientist at the Purdue University Center for Cancer Research, studied the compound and discovered a cost-effective and efficient way to synthesize it in the lab. The compound -- curcusone D -- has the potential to help combat a protein found in many cancers, including some forms of breast, brain, colorectal, prostate, lung and liver cancers, among others. The protein, dubbed BRAT1, had previously been deemed "undruggable" for its chemical properties. In collaboration with Alexander Adibekian's group at the Scripps Research Institute, they linked curcusone D to BRAT1 and validated curcusone D as the first BRAT1 inhibitor.

Curcusones are compounds that come from a shrub named Jatropha curcas, also called the purging nut. Native to the Americas, it has spread to other continents, including Africa and Asia. The plant has long been used for medicinal properties -- including the treatment of cancer -- as well as being a proposed inexpensive source of biodiesel.[...] Researchers tested the compounds on breast cancer cells and found curcusone D to be extremely effective at shutting down cancer cells. The protein they were targeting, BRAT1, regulates DNA damage response and DNA repair in cancer cells. Cancer cells grow very fast and make a lot of DNA. If scientists can damage cancer cells' DNA and keep them from repairing it, they can stop cancer cells from growing.

"Our compound can not only kill these cancer cells, it can stop their migration," Dai said. "If we can keep the cancer from metastasizing, the patient can live longer."

Stopping cancer from spreading throughout the body -- metastasizing -- is key to preserving a cancer patient's life. Once cancer starts to migrate from its original organ into different body systems, new symptoms start to develop, often threatening the patient's life.

"For killing cancer cells and stopping migration, there are other compounds that do that," Dai said. "But as far as inhibiting the BRAT1 protein, there are no other compounds that can do that."

Dai and his team believe that as effective as curcusone D is by itself, it may be even more potent as part of a combination therapy. They tested it alongside a DNA damaging agent that has already been approved by the Food and Drug Administration and found that this combination therapy is much more effective.

One difficulty in studying curcusones as potential cancer treatments is that, while the shrub they come from is common and inexpensive, it takes massive amounts of the shrub to yield even a small amount of the compounds. Even then, it is difficult to separate the compounds they were interested in from the rest of the chemicals in the shrub's roots.

"In nature, the plant doesn't produce a lot of this compound," Dai said. "You would need maybe as much as 100 pounds of the plant's dry roots to get just about a quarter teaspoon of the substance -- a 0.002% yield."

That small yield is relevant for production, because if it is effective as a cancer treatment, pharmacists will need a lot more of it. Additionally, having an abundant supply of the compounds makes studying them easier, quicker and less expensive.

"That's why a new synthesis is so important," Dai said. "We can use the synthesis to produce more compounds in a purer form for biological study, allowing us to advance the field. From there, we can make analogs of the compound to improve its potency and decrease the potential for side effects."

The next step will be to test the compound to ensure that it is not toxic to humans, something the researchers are optimistic about since the shrub it came from has been used as a traditional medicine in a number of cultures. Already, researchers from other entities have reached out to test the compound on the cancers they study, bringing hope for renewed therapeutics for treating the disease.

"Many of our most successful cancer drugs have come from nature," Dai said. "A lot of the low-hanging fruit, the compounds that are easy to isolate or synthesize, have already been screened and picked over. We are looking for things no one has thought about before. Once we have the chemistry, we can build the molecules we're interested in and study their biological function."
Sex is great. But have you tried data visualizations of partisan spatial segregation?
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the white man still cries when you cut down the lynching trees


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Greater Miami Shores
Powerbroker
 
Posts: 9052
Founded: Aug 06, 2010
Capitalist Paradise

Postby Greater Miami Shores » Wed Apr 21, 2021 11:33 pm

Greater Cesnica wrote:

Nice, I like the sky too.
I once tried to K Me. Posted It and Reported. Locked by Mods. I am Autistic accounts for Repetitive Nature. I am Very Civil and Respectful to all on NS and off NS. My Opinions Are Not Bad Opinions No Ones Opinions Are Bad Opinons. We are on NS, to share, discuss, argue, disagree, on Trump, elections, Republicans, Democrats, Socialists, Libertarians and whatevers, with respect. This Respect Is Given It Is Not Earned, This Respect Is Called Freedom of Expression and Democracy. This Man Always Says What He Means, I Am The Real Thing. I Make Ted Cruz look like a Leftist. I have been on NS For over 10 Years with a Perfect Record of No Baiting, Trolling, Flaming, or Using Foul Language. I Am Very Proud of It and Wish To Keep My Record Clean. But I Am Not The Only One On NS. GMS. I'm Based.

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Thepeopl
Minister
 
Posts: 2009
Founded: Feb 24, 2019
Democratic Socialists

Postby Thepeopl » Thu Apr 22, 2021 1:35 am


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Reploid Productions
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Posts: 27930
Founded: Antiquity
Democratic Socialists

Postby Reploid Productions » Thu Apr 22, 2021 10:14 pm

Previously injured, rescued, rehabbed, and released little red flying fox returned 4 months later to the humans who helped her when she was hurt to get aid when she had her baby prematurely. With adorable cameo appearance by the likely father of the baby, Mr. Meep de la Coconuts (an unreleasable permanent-care bat named for his unique vocalization and his... urm... particularly generous pair of coconuts) who the carers suspect hooked up with Ms. Primrose when she was in care previously.
Last edited by Reploid Productions on Thu Apr 22, 2021 10:29 pm, edited 1 time in total.
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[violet] wrote:Maybe we could power our new search engine from the sexual tension between you two.
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The Huskar Social Union
Khan of Spam
 
Posts: 50871
Founded: Apr 04, 2012
Left-wing Utopia

Postby The Huskar Social Union » Fri Apr 23, 2021 3:23 am

A 14 year old girl who went missing from the Republic of Ireland and was spotted in North Belfast with an 18 year old man has been found by the Police after an extensive search.

I first learned about her being missing yesterday and was fully expecting to wake up one day and hear she had been killed or hurt in some way, so im glad they found her and can get her back home.
Irish Nationalist from Belfast / SDLP-Alliance Party / Leftwinger / Atheist
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Kowani
Post Czar
 
Posts: 37922
Founded: Apr 01, 2018
Democratic Socialists

Postby Kowani » Fri Apr 23, 2021 4:32 pm

Sex is great. But have you tried data visualizations of partisan spatial segregation?
The National Debt is not debt, but merely the sum total, to the penny, of every untaxed dollar in existence since the start of the nation.
Updating Trackers! How Congress votes, what Americans believe,world leader approvals, and police violence/misconduct!
Headline of the day: Chile votes on Assembly to rewrite Constitution from Pinochet's dictatorship
“Dale limona, mujer, que no hay en la vida ná, como la pena de ser, ciego en Graná”
the white man still cries when you cut down the lynching trees

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San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Fri Apr 23, 2021 4:37 pm

https://denver.cbslocal.com/2021/04/21/ ... WZ6keIjLpA

An incredible video of a mountain lion in the Boulder foothills.


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Maineiacs
Negotiator
 
Posts: 7079
Founded: May 26, 2005
Civil Rights Lovefest

Postby Maineiacs » Fri Apr 23, 2021 8:49 pm

Dog in Utah wins High School Varsity Girls' 4x200m relay:


https://www.youtube.com/watch?v=-RJT0DniWtM&t=125s
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Geniasis: Christian values are incompatible with Conservative ideals. I cannot both follow the teachings of Christ and be a Republican. Therefore, I choose to not be a Republican.
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San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Fri Apr 23, 2021 9:49 pm

Maineiacs wrote:Dog in Utah wins High School Varsity Girls' 4x200m relay:


https://www.youtube.com/watch?v=-RJT0DniWtM&t=125s

That’s one of the funniest things I’ve seen in a long time. Thank you for sharing that.

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Nevertopia
Minister
 
Posts: 2096
Founded: May 27, 2020
Left-Leaning College State

Postby Nevertopia » Sat Apr 24, 2021 1:07 am

new high paying job, settled in my new apartment, close to work, girlfriend living with me, overall things are going good. Might be retiring from this game soon. Ive essentially won already. 8) Someone on TET announced theyve graduated from college, man does time fly! Makes me want to do something else with my life, I'd feel real bad if I spent the same amount of time someone spent in college doing nothing but making factbooks or something all day.
Last edited by Nevertopia on Sat Apr 24, 2021 1:10 am, edited 1 time in total.
Down with the CCP
Communism has failed every time its been tried.
Civilization Index: Class 9.28
Tier 7: Stellar Settler | Level 7: Wonderful Wizard | Type 7: Astro Ambassador
This nation's overview is the primary canon. For more information use NS stats.
Black Lives Matter

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San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Sat Apr 24, 2021 6:43 am

https://www.bbc.com/news/uk-england-kent-56847548

Wildcats could return to England after 200 years.

The Wildwood Trust plans to start a breeding project, while researchers look for a suitable release site.

The return of the predators, which have been driven to extinction in England and Wales, could "help restore the balance in ecosystems," the trust said.
Last edited by San Lumen on Sat Apr 24, 2021 6:45 am, edited 1 time in total.

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Valentine Z
Postmaster-General
 
Posts: 10086
Founded: Nov 08, 2015
Scandinavian Liberal Paradise

Postby Valentine Z » Sat Apr 24, 2021 1:25 pm

So as a bit of a shameless plug, I do hobbyist photography for non-profit. ^^ I just hope that you guys enjoy and like looking at them, because I just like taking photos. ♥

It's been decades since I have been living in Singapore, and let's say this is the first time I have been to the Flower Dome and Cloud Garden. Thankfully, I don't have a pollen allergy.

-----

Also got quite a boxful of macarons from TWG recently. They got an one-for-one (50%) discount, and I am a big fan of the sweet little desserts.

-----

Might be also getting a technical interview for a job this coming week.


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San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Sat Apr 24, 2021 2:43 pm

https://www.goodnewsnetwork.org/antibio ... ted-coral/

Common Human Antibiotic Can Heal Coral Diseases – 95% Success Rate With Amoxicillin

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Nevertopia
Minister
 
Posts: 2096
Founded: May 27, 2020
Left-Leaning College State

Postby Nevertopia » Sat Apr 24, 2021 3:59 pm

a bit of negativity coming my way for some reason, I thought I'd reaffirm with all of you the things in my life Im thankful for.

I'm glad I have an university degree with a highpaying job that lets me live in the heart of the city, Im glad that my home is close to my workplace, Im glad I met my girlfriend in spite of covid last year, Im glad we moved in together, Im glad I learned all these new skills in cooking thai food from her, Im glad Im fit despite working in an office all day, Im thankful for my friends and co-workers who support and care about me, Im thankful my big sister is achieving success as a lawyer, Im proud of my little sister for being a nurse during Covid and helping people, I'm glad our parents haven't gotten sick, Im glad we all stay in touch even though we're cities away, Im glad we all love each other, Im glad my nation provided me with insights to how certain political beliefs turn out and Im glad this game hasn't consumed my life. 8)
Last edited by Nevertopia on Sat Apr 24, 2021 4:03 pm, edited 2 times in total.
Down with the CCP
Communism has failed every time its been tried.
Civilization Index: Class 9.28
Tier 7: Stellar Settler | Level 7: Wonderful Wizard | Type 7: Astro Ambassador
This nation's overview is the primary canon. For more information use NS stats.
Black Lives Matter

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San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Sat Apr 24, 2021 4:00 pm

https://www.allaboutbirds.org/guide/Ame ... /306710541

Saw the beautiful American Goldfinch in my yard today.

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Nevertopia
Minister
 
Posts: 2096
Founded: May 27, 2020
Left-Leaning College State

Postby Nevertopia » Sat Apr 24, 2021 4:03 pm

San Lumen wrote:https://www.allaboutbirds.org/guide/American_Goldfinch/media-browser/306710541

Saw the beautiful American Goldfinch in my yard today.


what a beautiful bird. So happy and peaceful.
Down with the CCP
Communism has failed every time its been tried.
Civilization Index: Class 9.28
Tier 7: Stellar Settler | Level 7: Wonderful Wizard | Type 7: Astro Ambassador
This nation's overview is the primary canon. For more information use NS stats.
Black Lives Matter

User avatar
San Lumen
Khan of Spam
 
Posts: 59136
Founded: Jul 02, 2009
New York Times Democracy

Postby San Lumen » Sat Apr 24, 2021 9:18 pm

https://variety.com/2021/film/news/wond ... 234904194/

Wizard of Oz’ Remake in the Works at New Line With Director Nicole Kassell. New Line promises the upcoming film will be a “fresh take” on Dorothy and the Land of Oz, adding that it can “draw on other elements” from Garland’s “Wizard of Oz” — like the prized ruby red slippers. I hope the new movie includes the famous songs including We're off to see the Wizard"

I have mixed feelings about this though. Why remake one of the greatest films ever made?
Last edited by San Lumen on Sat Apr 24, 2021 9:19 pm, edited 1 time in total.


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