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by Luminesa » Thu Mar 25, 2021 10:00 pm
San Lumen wrote:https://www.fox13news.com/news/endangered-black-rhinoceros-calf-born-at-florida-zoo
Zoo Miami has welcomed the newest member of its family: an endangered black rhinoceros calf. According to the zoo, 21-year-old Circe gave birth to a baby boy on Feb. 24 after a 15-month-long pregnancy. This is her fourth baby.
by Kowani » Thu Mar 25, 2021 10:50 pm
by The Blaatschapen » Fri Mar 26, 2021 1:41 am
by Silvedania » Fri Mar 26, 2021 4:10 am
News:All trade with Crabaiaia and Pikala has stopped as diplomats meet in Trenaka. Silvedanians are confused by Quentin Tarantulatino's new film, Seasonal Snackbox(This is a Bojack Horseman reference.) Weird song goes viral for making no sense.
by Ethel mermania » Fri Mar 26, 2021 5:15 am
Luminesa wrote:San Lumen wrote:https://www.fox13news.com/news/endangered-black-rhinoceros-calf-born-at-florida-zoo
Zoo Miami has welcomed the newest member of its family: an endangered black rhinoceros calf. According to the zoo, 21-year-old Circe gave birth to a baby boy on Feb. 24 after a 15-month-long pregnancy. This is her fourth baby.
The new baby rhino needs a name!
by San Lumen » Fri Mar 26, 2021 11:04 am
by San Lumen » Sat Mar 27, 2021 6:56 am
by Kowani » Sat Mar 27, 2021 7:41 pm
Australian researchers have discovered a new way to target an aggressive childhood cancer, neuroblastoma, one of the most common and dangerous cancers in young children. The discovery may also have important implications for some other aggressive cancers in children, including certain brain tumours, as well as some adult cancers, including ovarian and prostate cancer. [...] Working with neuroblastoma cells, Professor Marshall and his team found that ALYREF bound to MYCN directly to switch on another protein, USP3, which prevents MYCN being degraded. This maintains the extremely high levels of MYCN needed to drive the cancer, and so acts as an accelerant. These findings strongly suggest that ALYREF inhibition could interrupt this cycle and prove to be a very valuable new therapeutic strategy for high-risk neuroblastoma.
The next step will be to develop a potent and specific ALYREF inhibitor—a drug capable of inhibiting the actions of this molecule ? and to test this in laboratory models
"This research provides new knowledge as a basis for drug discovery," said Dr. Cheung. "Once we find a suitable drug candidate, we can take this to clinical trial in children with high levels of MYCN and ALYREF in their tumours."
Excitingly, targeting ALYREF may also prove to be a useful therapeutic strategy for other types of cancer which, like high-risk neuroblastoma, are known to be MYCN-driven. These include blood cancers, medulloblastoma, glioblastoma, retinoblastoma, ovarian cancer, Wilms' tumour, and neuroendocrine prostate cancer. Further research will be needed to explore this potential.
by Luminesa » Sat Mar 27, 2021 8:39 pm
Kowani wrote:World-first discovery paves way to new cancer treatment for childrenAustralian researchers have discovered a new way to target an aggressive childhood cancer, neuroblastoma, one of the most common and dangerous cancers in young children. The discovery may also have important implications for some other aggressive cancers in children, including certain brain tumours, as well as some adult cancers, including ovarian and prostate cancer. [...] Working with neuroblastoma cells, Professor Marshall and his team found that ALYREF bound to MYCN directly to switch on another protein, USP3, which prevents MYCN being degraded. This maintains the extremely high levels of MYCN needed to drive the cancer, and so acts as an accelerant. These findings strongly suggest that ALYREF inhibition could interrupt this cycle and prove to be a very valuable new therapeutic strategy for high-risk neuroblastoma.
The next step will be to develop a potent and specific ALYREF inhibitor—a drug capable of inhibiting the actions of this molecule ? and to test this in laboratory models
"This research provides new knowledge as a basis for drug discovery," said Dr. Cheung. "Once we find a suitable drug candidate, we can take this to clinical trial in children with high levels of MYCN and ALYREF in their tumours."
Excitingly, targeting ALYREF may also prove to be a useful therapeutic strategy for other types of cancer which, like high-risk neuroblastoma, are known to be MYCN-driven. These include blood cancers, medulloblastoma, glioblastoma, retinoblastoma, ovarian cancer, Wilms' tumour, and neuroendocrine prostate cancer. Further research will be needed to explore this potential.
by San Lumen » Wed Mar 31, 2021 7:56 am
by Thepeopl » Wed Mar 31, 2021 1:23 pm
San Lumen wrote:https://www.goodnewsnetwork.org/droneseed-uses-heavy-lift-drones-to-restore-forests-after-wildfires/
After Massive Wildfires DroneSeed is Replanting Forests 6x Faster By Using Special Drones
by Bear Stearns » Thu Apr 01, 2021 1:01 pm
by San Lumen » Thu Apr 01, 2021 2:58 pm
by New Jacobland » Thu Apr 01, 2021 5:34 pm
by San Lumen » Thu Apr 01, 2021 8:58 pm
by Kowani » Sat Apr 03, 2021 2:24 am
Here is what makes the version of Super Mario Bros. that sold today so special, according to Heritage Auctions:
Not only is this the finest plastic-sealed copy with a perforated cardboard hangtab we’ve ever offered of any black box title, it is also the oldest sealed copy of Super Mario Bros. we’ve ever had the opportunity to offer. This is only the fourth version of Super Mario Bros. ever produced, and its window of production was remarkably short. Just to paint a better picture of how short this really was — the nationwide release for the console came in mid to late 1986, and black box games distributed for that release did not have the “Game Pak NES-GP” code. It’s worth mentioning that Nintendo managed to add the trademark symbol to the Nintendo Entertainment System on their game boxes by the beginning of 1987. That certainly doesn’t leave much time at all for this variant to be produced in-between the two!
by San Lumen » Sat Apr 03, 2021 5:30 am
by Ethel mermania » Sat Apr 03, 2021 8:02 am
Thepeopl wrote:San Lumen wrote:https://www.goodnewsnetwork.org/droneseed-uses-heavy-lift-drones-to-restore-forests-after-wildfires/
After Massive Wildfires DroneSeed is Replanting Forests 6x Faster By Using Special Drones
And now it needs coffee ..
https://api.nationalgeographic.com/dist ... row-faster
by San Lumen » Sat Apr 03, 2021 8:09 am
by Kowani » Tue Apr 06, 2021 10:08 am
A novel vaccine approach for the prevention of HIV has shown promise in Phase I trials, reported IAVI and Scripps Research. According to the organisations, the vaccine successfully stimulated the production of the rare immune cells needed to generate antibodies against HIV in 97 percent of participants.
The vaccine is being developed to act as an immune primer, to trigger the activation of naïve B cells via a process called germline-targeting, as the first stage in a multi-step vaccine regimen to elicit the production of many different types of broadly neutralizing antibodies (bnAbs). Stimulating the production of bnAbs has been pursued as a holy grail in HIV for decades. It is hoped that these specialised blood proteins could attach to HIV surface proteins called spikes, which allow the virus to enter human cells, and disable them via a difficult-to-access regions that does not vary much from strain to strain.
by San Lumen » Tue Apr 06, 2021 10:12 am
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