Jesus says that "not the smallest letter, not the least stroke of a pen, will by any means disappear from the Law until everything is accomplished", which most Christians believe refers to the New Covenant. He also says that he is to fulfill the law, not enforce them. I don't have to tell you what fulfillment means to see how this changes the interpretation.
Regarding the rest, context is important. As in, the context of the quotation in the Bible. Namely that of the Sermon on the Mount. So when Jesus says that if people set aside the "least of these commands", he's referring to the commands he was giving and about to give. Further input by Jesus and the Apostles continue to show how the Judaic laws of the Old Covenant don't apply to Christians. Actual theologians feel free to correct me, but I think I've gotten the basic Christian interpretation right.